DBC relocated to newly built facilities on a 28-acre campus at 35700 W. Twelve Mile Road in Farmington Hills, Michigan, in 1978.

Five presidents led the college: Dr. Roy L. Aldrich, Dr. Wendell G. Johnston, Dr. William A. Shoemaker, Dr. James C. McHann, and Dr. Robert Hagerty.

Notable faculty who served over the years include Dr. Charles H. Shaw, Dr. Herbert Cocking, Dr. Matthew Parker, and Dr. Henry W. Holloman.

With the appointment of William Shoemaker as president in the mid-1980s, the college began to broaden its theological teaching perspective, a process that was met with mixed reaction from alumni and traditional constituents.

In 2001, Congressman Joe Knollenberg worked with Tyndale's President James C. McHann to secure almost $1.5 million in federal funding for the college.

In that same year, United States Senator Debbie Stabenow and Sen. Carl Levin also helped the college receive federal funding totaling $461,000.