[2] At the 1708 British general election, Vane was returned unopposed as Member of Parliament for County Durham on his father's interest.
He was active as a teller for various electoral disputes and voted for the naturalization of the Palatines, and for the impeachment of Dr Sacheverell.
The settlement dated 15 November 1703 included Fairlawn, Kent, and lands in Durham, providing Vane with £600 p.a.
After the marriage, Vane's father refused to include Fairlawn in the settlement, and took ‘great displeasure’ and stopped the allowance when his son took legal advice.
[3] Together, they were the parents of: Vane died of apoplexy on 20 May 1734 at Fairlawn, Shipbourne, Kent, where he was buried on 5 June.