William Wirt Vaughan (July 2, 1831 – August 19, 1878) was an American politician and a member of the United States House of Representatives for the 8th congressional district of Tennessee.
Vaughan was born on July 2, 1831, in LaGuardo (now Martha), Tennessee in Wilson County.
He attended the common schools and graduated from Cumberland University in Lebanon, Tennessee.
He studied law, was admitted to the bar in 1860, and commenced practice in Brownsville, Tennessee.
On August 19, 1878, Vaughan died, at age 47 years, 48 days, in Crockett Mills near Alamo, Tennessee, in Crockett County while canvassing the district.