[1] In 1943, Bill Woodson made his Broadway debut as Lowell Denton in Harriet, starring Helen Hayes.

From 1946–47, the actor played, what is probably his best-known stage role, Le Bret opposite Jose Ferrer as the title character in Cyrano de Bergerac.

He also appeared as Tom Mackenzie in The Seven Year Itch, Stephen Douglas in The Rivalry and T. Stedman Harder in A Moon for the Misbegotten.

Another on-screen role was as Sergeant Ed Blankey on the 1959–1960 drama television series This Man Dawson and as Major Dudley in 1960 in an episode of the situation comedy The Tom Ewell Show.

William Woodson's legacy will be his long association with the Super Friends series, where he served as narrator and sometimes voiced additional characters.

[1] In addition, he also supplied the opening narration and voice for several characters on Battle of the Planets, as well as playing the sinister tanner in Walt Disney's The Small One.

In 1994 Woodson was the voice of a television and radio advertising campaign celebrating the 30th anniversary of Pennsylvania-based Wawa convenience stores.

The commercials humorously referenced 1964 events such as The Beatles' appearances on The Ed Sullivan Show and the introduction of the Ford Mustang.

From 2004–2010, Woodson, a California resident, lent his austere deep voice to a series of humorous commercials promoting the Minnesota Twins.