One passenger airline operates Embraer 145s while FedEx Feeder flies freight out of Williamsport Regional Airport.

In late 2017 the airport began work on a brand new terminal building with seating for 150, limited food options, updated security features and a passenger loading bridge.

The airport company, with help from the Chamber of Commerce and the City of Williamsport, sold hundreds of shares of stock at $100 each until it had raised about $75,000, enough to buy 161 acres of a family farm in Montoursville.

In 1964 TWA Lockheed Constellations flew Boston - Albany, NY - Binghamton - Wilkes-Barre/Scranton - Williamsport - Pittsburgh - Columbus, OH - Indianapolis - St. Louis - Kansas City.

[15] In fall 1994 USAir Express, successor to Allegheny Commuter, flew Beechcraft 1900C and Short 360s to Philadelphia and BAe Jetstream 31s and Embraer EMB-120 Brasilias to Pittsburgh.

[17] Interline agreements with United, American, and Alaska Airlines will permit "seamless connections" including through-bag transfer.

In 2009 the airport authority and city leaders announced a $3 million budget to do minor renovation to the existing terminal, update tax-exempt and runway lighting and widen taxiways.

In 2016 the Williamsport Municipal Airport Authority began the bidding process for a new $15.9 million terminal which they planned to open by the end of 2017.

[18] A grant of $798,000 was given to the airport which installed a new glide slope system, access road and repainted airfield taxiway and runway lines.

[1] In 2016 the airport had 33,019 aircraft movements, average 90 per day: 70% general aviation, 19% air taxi, 9% airline and 2% military.

Energy Aviation is the fixed-base operator; there are hangars and the headquarters of Life Flight air ambulance service.

Mostly from Harrisburg, Fort Indiantown Gap, or the air reserve station in Pittsburgh, they mostly perform TGL maneuvers and re-fueling stops due to its low commercial traffic and up to date facilities.