The community developed where the major road between Batavia and Buffalo crossed Ellicott Creek just above Glen Falls.

[4] A stagecoach stop, tavern, and inn was built along the main road near Ellicott Creek by Oziel Smith in 1827.

[5] The close crossing of the main road and Ellicott Creek's Glen Falls was the initial attraction, around which Williamsville grew.

American soldiers and British prisoners were treated in a field hospital and log barracks that lined Garrison Road.

A small cemetery, located on Aero Drive between Wehrle and Youngs Road, was used to bury the men who did not survive.

General Winfield Scott used the Evans House as his headquarters in the Spring of 1813 when his entire army of 5,000–6,000 men were stationed in Williamsville.

In 1813, when the British burned Buffalo, people fled to the safety of Williamsville, nearby Harris Hill, and Erie, Pennsylvania.

In 1983, Williamsville passed a Historic Preservation Code "to promote the awareness of landmarks of historic, cultural, social and architectural significance in the Village of Williamsville and to safe guard the heritage, character and quality of life unique to the Village through the preservation of these landmarks.

"[7] Every summer in Williamsville, Old Home Days[8] is held in Island Park, located directly on Main Street in the village.

The Old Home Days festival is in remembrance of several women who in the mid-19th century came to the park once each summer to drink tea and catch up on the years past.

[9] According to the United States Census Bureau, the village has a total area of 1.2 square miles (3.1 km2), all land.

American surveyor Joseph Ellicott had the "Great Iroquois Trail", an ancient path from the Hudson River to Lake Erie, improved.

Transit Road marks the boundary between townships (Amherst and Clarence, Cheektowaga and Lancaster), inter alia.

A Thruway toll plaza located near the village has been a matter of controversy for years and recent proposals suggest it may be moved farther east.

The private schools of Williamsville include Saints Peter and Paul (Roman Catholic Diocese of Buffalo), as well as Christian Central Academy.