Isa previously played one NRL match for the Penrith Panthers, called up unexpectedly at half-time in a NYC game to replace an injured player.

[4] Isa was signed by Melbourne for the 2009 NRL season and he was compared to the Storm's former star player, Israel Folau.

[11] In round 20 of the 2021 Super League season, Isa was sent to the sin bin and placed on report for another incident in Wigan's 26–2 loss against St Helens.

[13] On 14 October 2023, Isa played in Wigan's 2023 Super League Grand Final victory over the Catalans Dragons.

In the post match celebrations, Sky Sports presenter Brian Carney described Isa as a "junkyard dog".