The idea of opening a new academy in the neighborhood had been in the air ever since the closing in 1834 of the Round Hill School in nearby Northampton.

Luther Wright, its principal from 1841 to 1849, believed it was desirable to have his pupils study together in a single room under his direction.

However, the school's student population grew rapidly and the one-room schoolhouse scheme was soon no longer practicable as more instructors and new buildings were added.

In the late 19th century, the dual curricula had evolved into a more modern comprehensive course (e.g. with "scientific and preparatory departments"),[7] and in 1924 the school was renamed Williston Academy.

[12] The Dodge Room is the setting for many guest speakers, including the school's Writers' Workshop series.

[13] After a fire destroyed the school's theater building in 1994, it was rebuilt adjacent to the science laboratories, Scott Hall.

It was created in 1972 in honor of the Northampton School for Girls founders Sarah B. Whitaker and Dorothy M. Bement.