It was established in 1832 and is the oldest continually operating eye-care facility in the United States.

Since 1990, Wills Eye Hospital has consistently been ranked one of the top three ophthalmology hospitals in the United States by U.S. News & World Report and its ophthalmology residency program is considered one of the most competitive residency programs in the world.

and Isaac Hays, MD,[2] George Fox, M.D., and Squier Littell, M.D., who in 1837 wrote "A Manual of Diseases of the Eye.

"[3] In 1854, Littell also co-edited "A Treatise on Operative Ophthalmic Surgery" with Henry Haynes Walton.

[4] The Centennial Building of Wills Eye Hospital was designed by architect John T. Windrim and built in 1931-1932.