In his lone full season for the senior team, he averaged 5.7 points and 3.3 rebounds in 34 games in the Spanish ACB League.

[5] On 25 October 2016, he made his debut for the Knicks in their season opener, scoring four points in nine minutes off the bench in a 117–88 loss to the Cleveland Cavaliers.

[10] On 15 February, he was named as a replacement on the World Team for the injured Emmanuel Mudiay in 2017 Rising Stars Challenge.

[15] On 7 February 2018, Hernangómez was traded to the Charlotte Hornets in exchange for Johnny O'Bryant III and two future second round draft picks.

[17] On 12 July 2023, Hernangómez signed a lucrative three-year deal with Spanish powerhouse FC Barcelona, after his former club Real Madrid decided not to match the offer sheet as per the domestic league rule of tanteo rights.

At EuroBasket 2022, Hernangómez and Spain won a surprising gold medal after defeating France in the final, in which he had 14 points and 8 rebounds.