After making his Primeira Liga debut for Portimonense at the age of 23 he transferred to Porto for €7 million in 2019, going on to play 130 games and win two league and Taça de Portugal doubles.

[4] He made his professional debut with their reserves in the Segunda Liga, his first appearance in the competition being on 11 August 2013 when he came on as a 43rd-minute substitute in a 1–0 away loss against Atlético Clube de Portugal.

[17] He made his debut nine days later in a 3–0 home win over B-SAD, playing the final ten minutes in place of Éder Militão,[18] and scored his first goal on 4 May in a 4–0 defeat of C.D.

[20] Manafá started regularly under Sérgio Conceição, but eventually lost his position to João Mário on the right flank and Zaidu Sanusi on the left.

[24] Still injured, Manafá was one of four Porto players suspended for the 2022 Supertaça Cândido de Oliveira and fined €510 for having made insults towards Benfica during title celebrations.

[27] Having arrived injured, he only made five appearances during his spell in Andalusia,[28] his league bow coming on 5 November in a 1–0 away loss to Valencia CF where he played ten minutes.