He later signed as an undrafted free agent with the San Francisco 49ers in 2019, but did not make the team during final roster cuts, ending his NFL career.

[4] He was a highly recruited Virginia high school athlete who was being recruited by the likes of Virginia Tech until a severe collarbone injury during the first game of his fall 2011 junior season that required a metal plate and eight screws to repair caused most schools to lose interest in him.

[2] Speight hired quarterback guru Steve Clarkson to help him regain his form and posted 2,900 yards and 32 touchdowns in ten games during the 2012 season.

"[12] Sources: In early February 2013, Speight received a scholarship offer, and promptly verbally committed, to play college football at the University of Michigan.

[17] Speight redshirted his entire freshman season for the 2014 Wolverines as fifth-year senior Devin Gardner led the team.

Speight made his Michigan debut on September 12, 2015, taking kneel-down snaps in the closing minutes of a victory over Oregon State.

[18] Harbaugh ultimately decided to redshirt Morris during the 2015 season, resulting in Speight seeing playing time as Rudock's principal backup.

[20][21] The two-point conversion gave Michigan a three-point lead that forced Minnesota into a decision to attempt to score a touchdown on the goal line as time expired.

[37][38] On October 1, Speight's tiebreaking fourth quarter touchdown pass to Amara Darboh against #8-ranked Wisconsin lifted Michigan to its first win against a top-10 opponent since the 2008 Wolverines beat the 2008 Badgers,[39] ending a streak of 12 consecutive such losses.

[42] Two days later, it was reported that Speight had endured a broken collarbone during the game and was feared lost for the rest of the season.

[44][45] Following the season, Speight was the third team All-Big Ten quarterback selection by both the coaches and the media (behind J. T. Barrett and Trace McSorley).

[54] On November 13, head coach Jim Harbaugh stated that Speight was cleared to participate in non-contact football activities.

[58] On August 30, 2018, it was announced that Speight had been named by new head coach Chip Kelly as the starting quarterback for the Bruins' season opener against Cincinnati.

[59][60] Speight suffered a back injury in the opener (an eventual 26–17 loss) and was replaced with true freshman Dorian Thompson-Robinson in the second quarter.

[61][62] Speight did not see game action again until the Bruins' matchup with the Arizona Wildcats on October 20, when Thompson-Robinson suffered an injury in the second quarter.

[64] On November 17, Speight completed 13 of 22 passes for 166 yards, one touchdown, and one interception as UCLA defeated its crosstown rival, the USC Trojans, 34–27.