Produced by Suga of BTS, the song is a hip hop and R&B track with elements of electropop and future bass, and was written by Suran, Slow Rabbit, Changmo, and June.

[2] Composed by Suga of BTS, the song was written by Suran, Big Hit producer Slow Rabbit, rapper Changmo, and June,[a] and tells the story of an individual reminiscing about memories of a former lover over a glass of wine.

Through that introduction, both artists developed a working music relationship[5] which led to Suran appearing as a featured vocalist on the track "So Far Away" for Suga's 2016 mixtape Agust D.[6] On April 21, 2017, Million Market and Big Hit Entertainment announced news of a special collaboration between the two.

He played the demo for what would become "Wine" for her in the studio and after hearing it, she felt it was "bright" and the "atmosphere was good" so they began working on the track together.

Million Market officially confirmed later that day that the rapper featured on the track, further increasing interest in the song as Changmo was well known as a "skilled, trendy rapper" at the time, having recently released a collaboration of his own with singer Hyolyn that performed well on the music charts and earned him the moniker of "music powerhouse" by news media.

[10][11] The cover art for "Wine" was revealed the morning of April 27, 2017, hours before the song's release,[12] and featured a long-haired, flushed-faced girl (to intimate she had been drinking) in a white dress staring into the camera with a "dreamy expression".

[13] The song was released at noon[14]—as the first single from the singer's then upcoming debut mini album[15]—and made available for streaming and digital download on various music sites.

[40] "Wine" was nominated for Best Vocal Performance – Female[41] at the 2017 Mnet Asian Music Awards, but lost to "You, Clouds, Rain" by Heize.

[46] "Wine" also received a nomination for Song of the Year – April[47] at the 7th Gaon Chart Music Awards held in February, but lost to "Palette" by IU.