The village is situated north of the Großes Bruch marshland and west of the Magdeburg Börde, with good soil quality in the surrounding area.

The municipal area comprises Winnigstedt proper and the southern quarter of Mattierzoll, which has been a toll station on the road from Wolfenbüttel to Halberstadt (called Hessendamm, present-day Bundesstrasse No.

It allowed travellers to cross the wetland on a causeway connecting the Brunswick-Lüneburg lands in the north with the territory of the Prince-Bishops of Halberstadt in the south.

After World War II, it bordered on the Soviet occupation zone, later the German Democratic Republic, and the road was closed until the Peaceful Revolution in 1989.

The present-day municipality was established in 1939 by merging the two villages of Groß and Klein Winnigstedt.