The station is situated roughly on the border between central Winterthur (to its west) and the Grüze industrial area (to its east).

The station was built in 1855, and used for the first time on 14 October of that year for Sankt Gallisch-Appenzellische Eisenbahn scheduled service on the Winterthur–Wil railway.

Initially, due to its operator's lack of permission to enter Winterthur Hauptbahnhof, that line's termini were Grüze and Bauma.

Since November 2002, Grüze has been a self-service station and the signal box has been automatically remote controlled.

As the station is located within the Grüze industrial area, it was formerly the scene of a lot of cargo handling.

A special feature of these shelters is the central support tube with platform numbers at its ends, from which the cantilever roofs protrude on both sides.