New boundary changes implemented, McVey stood again and won the seat for the Conservatives at the 2010 general election, serving in the coalition government as a Work and Pensions minister during her tenure.

Wirral West had been described as a bellwether since its establishment,[4][5] but bucked the trend at the 2015 general election when Labour's Margaret Greenwood narrowly defeated McVey, despite the Conservatives winning a parliamentary majority.

Like the nearby City of Chester, the seat was one of the few Conservative-held marginals outside of London to be gained by Labour, who benefited from the constituency's collapse in Liberal Democrat support.

Sixth on the Conservative target list in 2017, Greenwood was comfortably re-elected to Wirral West with the highest winning vote share since the seat was first up for election in 1983.

2010–2024: Metropolitan Borough of Wirral wards of Greasby, Frankby and Irby, Hoylake and Meols, Pensby and Thingwall, Upton, and West Kirby and Thurstaston.