The highway crosses Wisconsin and Southern Railroad tracks and heads east to a junction with Interstate 43 at Exit 21.

Highway 50 continues southeast out of Delavan, crossing Delavan Lake at the city's eastern border, and intersects Highway 67 north of Williams Bay.

Shortly after this intersection, Highway 50 meets U.S. Route 12 at Exit 330.

The highway continues eastward from Lake Geneva to the border of Kenosha County.

The route of Highway 50 through Kenosha changed in 1997; the highway moved from 75th Street to a more northerly alignment along Roosevelt Road and 63rd Street.