It runs east–west in southern Wisconsin from Prairie du Chien on the Mississippi River at the Iowa state line to the village of Grafton near Lake Michigan.

At the eastern approach, the concurrency briefly becomes a one-way pair before turning south.

After traveling south, they then briefly curve east just north of the Prairie du Chien Municipal Airport.

At this point, WIS 60 closely parallels the north side of the Wisconsin River.

After leaving US 61, it passes through Westport, Sand Prairie, and Port Andrew.

At Lone Rock, WIS 130 travels eastward along the concurrency for 2⁄3 mile (1.1 km).

In downtown Sauk City, WIS 60 turns northward along the west side of the river.

Continuing east past Columbus, they then pass through Astico and Lowell.

At this point, WIS 60 ends there and continues on as County Trunk Highway Q (CTH-Q).