It runs north–south in south central Wisconsin from the Illinois border near Monroe to Verona.

At the state line, WIS 69 turns into Illinois Route 26 (IL 26), which runs southward to Freeport.

WIS 69 splits off at another diamond interchange just east of the first, and turns back northward towards Monticello.

Three miles (4.8 km) north of New Glarus, WIS 69 enters Dane County.

WIS 69 passes through the unincorporated communities of Basco and Paoli before reaching the south edge of Verona, where it terminates at a diamond interchange with US 18 and US 151.