Wise Blood is a 1979 black comedy drama film directed by John Huston and starring Brad Dourif,[1] Dan Shor, Amy Wright, Harry Dean Stanton, and Ned Beatty.

Hazel "Haze" Motes is a 22-year-old veteran of an unspecified war and a preacher of the Church of Truth Without Christ, a religious organization of his own creation, which is against any belief in God, an afterlife, sin, or evil.

The protagonist comes across various characters such as teenager Sabbath Lilly Hawks, who is madly in love with him; her grandfather Asa Hawks who is a conventional sidewalk preacher, and pretends to be blind; and a local boy, Enoch Emery, who finds a "new" Jesus at the local museum in the form of the tiny corpse of a shrunken South American Indian.

[2] After her proposal of marriage is spurned by Motes, and he leaves, the landlady calls the police and reports him as derelict in paying rent.

Wise Blood was filmed mostly in and around Macon, Georgia, near O'Connor's home Andalusia in Baldwin County, using many local residents as extras.

It is so eccentric, so funny, so surprising, and so haunting that it is difficult to believe it is not the first film of some enfant terrible instead of the thirty-third feature by a man who is now in his seventies and whose career has had more highs and lows than a decade of weather maps.

It pulls off the rare trick of seeming faithful to the spirit and voice of the book, while being a work of art in its own right.

"[7] Marjorie Baumgarten from The Austin Chronicle wrote, "Disturbing and grim in its portraits, Wise Blood is nevertheless marvelous storytelling and its performances are virtually divine.

The site's critical consensus reads, "Director John Huston and author Flannery O'Connor prove a formidable creative match in Wise Blood, a gothic satire anchored by Brad Dourif's vinegary performance.