[2] These five members then recruited Michael Bohn of A Path Less Traveled and Hance Alligood of Oh, Manhattan as the band's initial vocalists.

[3] Whilst in the band, Mulkey helped write lyrics and record vocals for their original three demos, "Hell, or High Water", "I" and "If Not, for Ourselves", with producer Cameron Mizell before leaving.

The group later recorded and released a cover of the Kesha song "Tik Tok", also showcased online within a few months of being a band.

[8] Clean vocalist Tyler Carter's soul-influenced voice garnered comparisons to Jonny Craig, who provides guest appearances on the album.

[9][10][11][12][13] The group held an album release show in Georgia for Number[s] on September 2, 2010, with pop punk band Veara as a supporting act.

Later in September, the band recorded a cover of the Katy Perry song "Hot n Cold" for the compilation album, Punk Goes Pop 3.

In an interview with radio station The Gunz Show, Carter stated that the band would be recording a music video for "[&] Delinquents" in September 2010.

He cited an interest in following newer and different objectives than being in a band and went on to state that "[the rock 'n' roll lifestyle] and what it consists of just isn't for me anymore" as the reason for his departure.

[25] On September 15, 2011, Woe, Is Me announced via-video update the return of the band's original clean vocalist, Hance Alligood.

with We Came as Romans, The Acacia Strain, Oceano, Like Moths to Flames, Close to Home, Impending Doom, Abandon All Ships, Secrets, Volumes, For All Those Sleeping, The Chariot, Glass Cloud, At The Skylines, Texas in July, In Fear and Faith, and Hands Like Houses.

On March 8, 2013, the band released a statement that they had parted ways with drummer and founding member Austin Thornton, due to personal differences.

A recent interview with the band and lead singer Hance in particular gave insight towards the feel of the new album that they are working on.

Before the new EP dropped, Andrew Paiano had an emergency forcing him to leave in late July and the group continued playing Warped Tour as a 5-piece.

Woe, Is Me included a personal post from vocalist Hance Alligood stating that he had "lost passion" for the genre and had decided to leave the band on good terms.

On July 25, 2022, Woe, Is Me alluded to the fact that the band would be reforming with the lineup from their 2011 "Vengeance" single (Michael Bohn, Hance Alligood, Andrew Paiano, Kevin Hanson, Austin Thornton, and both Ferris brothers).