Wolf Bros formed in 2018 as a trio, with Bob Weir on guitar and vocals, Don Was on double bass, and Jay Lane on drums.

[5][6] On New Year's Eve 2020 Bob Weir & Wolf Bros, with Jeff Chimenti on keyboards and Greg Leisz on pedal steel guitar, livestreamed a concert from TRI Studios.

The band played several more shows at TRI Studios in the spring of 2021, with an expanded lineup including Chimenti, Leisz, and a horn and string section called the Wolfpack, with Brian Switzer on trumpet, Adam Theis on tenor trombone, Sheldon Brown on tenor and alto saxophone, clarinet, bass clarinet, flute and bass flute, Mads Tolling on violin, and Alex Kelly on cello.

[7][8] In June 2021 the band, now billed as Bobby Weir & Wolf Bros, performed four concerts in Colorado,[9] and in July they played one show in California.

[11][12][13] Bobby Weir & Wolf Bros, accompanied by the Wolfpack, played a spring 2022 concert tour with a lineup including Barry Sless on pedal steel guitar.