In 1968, he received his Ph.D. from Ludwig Maximilian University with his doctoral thesis on "The role of telencephalic commissures in bilateral EEG-synchrony."

The institute, with its technically elaborate experiments, is primarily concerned with the binding problem, where the question is at the center of how different sensory aspects of an object – form, color, hardness, weight, smell, etc.

Singer represents a naturalistic interpretation of neurophysiological data and strives to make the results of brain research known to the public.

[2] Singer, like Gerhard Roth, became the focus of public discussions in Germany through interviews, lectures and popular science essays regarding the consequences of neurological research to political and juridical, psychological and developmental psychology, pedagogical or anthropological, as well as architectural or urban questions and even to historical and philosophical views.

This he expressed publicly in an article published in the Frankfurter Allgemeine Zeitung in 2004, whose subtitling he made in the slightly modified formulation "Brain structures determine us: We should stop talking about free will" as the main title of the reprinting of an extensive scientific contribution to the discussion "Brain as a Subject?

Singer argues that the natural scientific causal model, according to which the world is to be viewed as a closed deterministic whole, excludes freedom.

Singer also demands that the lack of free will must have consequences for our conceptions of guilt and punishment: if no one can decide freely from a scientific point of view, it is not useful to make people responsible for their actions.

[3] In 2004, Wolf Singer was one of the authors of Das Manifest, a declaration of eleven leading neuroscientists on the presence and future of brain research, published in the magazine Gehirn & Geist.

He was also honored in France becoming a knight of the National Order of the Legion of Honour (Chevalier of the Légion d'honneur).