Wolff–Chaikoff effect

The Wolff–Chaikoff effect[1] is a presumed reduction in thyroid hormone levels caused by ingestion of a large amount of iodine.

research into the study shows that the thyroid hormone levels of the rats were not checked prior to injections.

Hyperthyroid subjects given iodide may experience a decrease in basal metabolic rate that is comparable to that seen after thyroidectomy.

It is to be distinguished from the Plummer effect, which inhibits the proteolysis of thyroglobulin and the release of pre-formed thyroid hormones from follicles.

[14] Only the Wolff–Chaikoff effect is helpful to prevent the thyroid from uptaking radioactive iodine in the case of nuclear emergencies.