It is an important structure that plays a critical role in the formation of male reproductive organs.
It also serves as the primordium for male urogenital structures including the epididymides, vasa deferentia, and seminal vesicles.
In a male, they develop into a system of connected organs between the efferent ducts of the testis and the prostate, namely the epididymis, the vas deferens, and the seminal vesicle.
Testosterone binds to and activates androgen receptor, affecting intracellular signals and modifying the expression of numerous genes.
In the female, with the absence of anti-Müllerian hormone secretion by the Sertoli cells and subsequent Müllerian apoptosis, the mesonephric ducts regress, although inclusions may persist.