[1] The UWLX was established by United Women's Sports in 2016,[2] and played three seasons before quietly disbanding.

[10][11][12] The establishment of the Women's Lacrosse League was announced by PLL President Paul Rabil on the November 13, 2024 broadcast of Get Up on ESPN.

[10][13] U.S. national team players Lizzie Colson, Ally Mastroianni, and Charlotte North, former Northwestern Wildcats midfielder Izzy Scane, and Athletes Unlimited assistant coach Alex Aust Holman, were also simultaneously unveiled as the league's first five signings.

[9][11][14] All but Colson were later appointed captains of each of the four charter clubs: the Boston Guard, California Palms, Maryland Charm, and New York Charging – the brandings of which were unveiled on a December 10 broadcast of ESPN's SportsCenter.

[12][20] Sixes also features thirty-second shot clocks and quick restarts initiated by the goaltender.