At the age of 12, he was selected as a naval cadet; at 16, he was sent to England to study naval engineering, then to the United States to study aeronautical engineering at the Massachusetts Institute of Technology (MIT) during the period of great social and political upheaval in China.

In May 1916, the fledgling Boeing Airplane Company hired Wong as their first trained aeronautical engineer.

[4] In light of the financial windfall brought from the Navy purchases, "from Bill Boeing onward, the company's chief executives through the decades were careful to note that without Wong Tsu's efforts, especially with the Model C, the company might not have survived the early years to become the dominant world aircraft manufacturer.

[6] When the Kuomintang government was defeated in the Chinese Civil War, Wong went to Taiwan where he became professor of aviation at National Cheng Kung University.

[7] In 2004, Boeing unveiled a plaque and exhibit at the Museum of Flight in Seattle, Washington, honoring Wong's work as its first engineer.