Logs not destined for Woods' mill were released gradually to avoid jams in the Ox Bow meadow downstream.

[5] The Boston, Concord & Montreal Railroad opened at Woodsville in 1853 and built its division offices and a branch repair shop.

It replaced the original 1805 bridge between the states with a two-level span, featuring a toll highway below and railroad tracks on the roof.

[6] The village boomed into an important railway town and junction, endowed with fine examples of Victorian architecture.

Woodsville serves as the commercial center for the town of Haverhill and the surrounding communities, including several just to the west in Vermont.

Many of the town's commercial businesses, including supermarkets, sit-down and fast-food restaurants, and banks, are located near the junction of US 302 and NH 10.

[12] In Robert Frost's narrative poem, "A Hundred Collars" (North of Boston), Doctor Magoon is forced to share a room overnight with the loquacious Lafe in Woodsville, "a place of shrieks and wandering lamps/And cars that shook and rattle—and one hotel."

[citation needed] In 2017, the Oxygen network produced a six-part television documentary miniseries titled The Disappearance of Maura Murray, hosted by journalist Maggie Freleng.