It was founded in 1975 and operated as a "college without walls" in the two counties for 20 years before constructing a campus in Salisbury in 1994.

In 1989, state legislation was enacted to allow Somerset County residents to attend Wor-Wic at the in-county tuition rate.

[5] In addition, Wor-Wic owns Ocean Resorts Golf Club which is used for their Turf Management and Hospitality courses.

[6][7] In 2023, Wor-Wic opened the new Patricia and Alan Guerrieri Technology Center, bringing "welding, HVACR, metal fabrication and plumbing labs; a CDL simulation lab; and other hands-on instruction areas for electro-mechanical, construction, electrical and alternative energy programs" on-campus.

A seven-member Board of Trustees, appointed by the Governor of the State of Maryland, governs the college.