During spring of 1935, the railway operator opened a special "plum blossom-sightseeing" train to Shanghai.

A new waiting room of 1,840 square meters (19,800 sq ft) located west of the existing station building was started its construction in June 1969.

[5]: 670 Shanghai Railway Bureau and the Municipality Government of Wuxi reached an agreement on the reconstruction of the station building in 1978.

[7] As the part of the transition construction, a new ticket office of 512 square meters (5,510 sq ft) was constructed during November 1981 and June 1982, a new signal house was constructed in 1983 and a temporary waiting room was built in the station square in 1985, 6 ticket counters were added in the same year; meanwhile, the freight services of carload lots were moved to South Gate Freight Yard.

The new station occupied the size of 12,500 square meters (135,000 sq ft), with 4 waiting rooms inside.

The station yard has 3 platforms and 6 tracks, with the effective lengths of 650 meters (2,132 ft 7 in) each.

[9][10] The Municipal Government of Wuxi invest money to renovate the south station square in September 2002,[11] which makes it one of the three large urban transformation projects of Wuxi in the 21st century along with Taihu Avenue and Taihu Plaza.

[7] The Non-stop express Z1 and 2 between Beijing and Shanghai added Wuxi Railway Station as the only intermediate stop on July 1, 2005.

[13] The electrification construction of the station yard started in 2006, the existing flyover was reconstructed to allow enough space for installing overhead line below.

[15] On April 18, after the Sixth Speed Up Campaign, the station began the operation of D-series train on Beijing–Shanghai railway, and had 2 D-trains to Shanghai.

[16] On October 21, 2008, Wuxi station is the only intermediate stop for the first EMU Sleeper train D301/2 of China Railway.

[23] In 2012, the planning department modified the comprehensive renovation plan to "renovate the south station building and construct ordinary canopies over the conventional train platforms" due to the consideration of the budgets.

[26] The renovation of the conventional yard were started afterward by the order of south to north: platform 1 and 2 was re-opened on July 18, 2018, and the southern part of the new waiting room that is above the conventional yard tracks was opened on February 6.

[29] Plus, a new ticket counters located on the first floor of the north station building were oepend on May 20, 2017.

The B1 floor is the arrival area with several stores, there are 10 ticket gates in the south exit.

[29] In the south station square, the drop-off area was in the eastern part, while the bus terminal is located on the both side.

He wrote the name for free under the request by the construction people in 1987 during the reconstruction of the third generation of the station building.

After the facade renovation of 2005, the signs were replaced by the computer fonts and caused the controversies among local citizens, then the station re-produced the calligraphy signs with English names using acrylic glass afterward.

[37] The north station and the elevated waiting room was connected by a flyover over the Xingchang Road.