Wyśmierzyce [vɨɕmjɛˈʐɨt͡sɛ] is a town in Białobrzegi County, Masovian Voivodeship, Poland, with 884 inhabitants (2004).

Historically Wyśmierzyce belongs to the region of Mazovia, and is located close to its border with Lesser Poland.

In 1378, first Roman Catholic parish was opened here, and in 1657, the town was completely destroyed by the army of Transilvanian prince George II Rakoczi during the Swedish Invasion of Poland.

Following the Third Partition of Poland, in 1795, it fell to Austria, within which it was administratively part of so-called West Galicia.

Following the duchy's dissolution, the town fell to Russian-controlled Congress Poland, from 1844 on as part of Radom Governorate.