In the spring of 1765, the Moravian Christian Munsees, a group of absolute pacifists, founded a settlement Friedenshütten (Tents or Cabins of Peace) in what is now Wyalusing.

This settlement lasted for several years, but was finally abandoned when the group led by David Zeisberger moved to Schoenbrunn (near Gnadenhutten, Ohio) in 1772.

[8] In the 19th century, the town began to prosper as it became a shipping area for logs and other items on the Susquehanna River.

[8] Many of the buildings constructed in the late 19th century and early 1920s are still part of Main Street today.

Wyalusing is home to one of the biggest beef processing plants on the East Coast.

Cargill is one of the biggest suppliers of ground beef to large grocery chains such as Wegmans, Giant, Shop Rite and more.

In 2002, the Taylor family sold the business to the Cargill corporation, one of the largest privately owned companies in the United States.

The Rocket Courier covers the surrounding Wyalusing area, as well local towns nearby.

[15] The Daily Review, founded in Towanda in 1879, acquired by the publishers of the Scranton Times in 1977 (now part of Times-Shamrock Communications), also provides Wyalusing coverage, serving Towanda, Bradford, and Sullivan counties, as well as Tioga County, New York.

[16] The Grovedale Winery[17] participates in the annual Wyalusing Valley Wine Festival, which is hosted by the Wyalusing Valley Museum Association, Inc.[18] This festival offers wine tasting, food, and dancing with many wineries from Northeastern Pennsylvania in attendance each year.