The Wyche Pavilion is the two-story, open-air shell of a historic building in downtown Greenville, South Carolina, used in the 21st century as an event venue.

As part of the Reedy River Industrial District, the building was listed in the National Register of Historic Places on January 14, 1979.

The brick structure was built in 1904 by noted Greenville engineer and industrial architect Joseph Emory Sirrine (1872–1947) with large windows of the same size on both floors, a flat roof, and a cupola at its center.

After financial constraints prevented the remodeling, the building was gutted, turned into an open-air pavilion, and named for Tommy Wyche (1926–2015) and his wife Harriet, leaders in the transformation of downtown Greenville.

In 2019, following the development of Falls Park, the Peace Center proposed to install windows, doors, and HVAC equipment in order to transform the building into "a fully-functioning performance venue, featuring state of the art sound and lighting".