Wye is an unincorporated community and census-designated place in Missoula County, Montana, United States.

The community is named for the "y"-shaped DeSmet Junction where US 93 and MT 200 met former US 10 (immediately south of US 10's replacement, I-90).

Missoula Montana Airport is 3 miles (5 km) southeast of Wye.

According to the U.S. Census Bureau, the Wye CDP has a total area of 2.9 square miles (7.5 km2), all land.

The racial makeup of the CDP was 92.65% White, 1.84% Native American, and 5.51% from two or more races.