Wye Mills is an unincorporated community in Talbot County, Maryland, United States, located at an altitude of 20 feet (6.1 m).

[1] Wye Mills is located at the intersection of Maryland routes 404 and 662, just south of the Queen Anne's County border.

[4] The Wye House is a plantation mansion listed on the National Register of Historic Places, dating back to between 1780 and 1790.

After the failure of the Oslo Accords of 1993 to resolve the Israeli–Palestinian conflict, former President Bill Clinton held a summit in Wye Mills in October 1998.

After Elián was reunited with his father, the two were sheltered from the media at the remote Wye River Plantation while other relatives attempted to acquire visitation rights and the legal battle intensified.