The village dates from at least 1086, when it was registered in the Domesday Book, though evidence has been discovered of paleolithic, Roman, and Saxon settlement in the area.

Throughout its history Wymington has been referred to by various names and spellings, including Wimmington, Winnington, Wimentone, Wimuntun, Widmintun, Wymingas, and other variations.

Flint implements have been discovered in the area, and in the 1860s a hoard of 60 socketed axes was found on a farm near Wymington, possibly from an ancient bronze smith's stock.

A complex of enclosures visible today in the form of cropmarks and ditches as well as buried roof tiles and sherds about 700 metres (770 yd) south of the modern village probably dates from the 1st to 5th century.

[9] Wymington was recorded in the Domesday Book of 1086 as a parish within the Hundred of Willey, a part of the barony held by Alured de Lincoln, with a population of 23 households.

He provided funds to re-build the village church, completed in 1377, and made a loan to Richard II in the sum of £20 in 1379, an extremely substantial amount at the time.

When Henry died without a male heir in January, 1468, the manor and all of his other holdings in Bedfordshire and Buckingham was sold off by the executors of his estate, with the proceeds going to charity and to the church.

In 1591, Henry, and later his son Ferdinando Stanley, 5th Earl of Derby, began to sell off large portions of Wymington to the manor in Podington.

[18] During the Second World War, families in and near Wymington took in children evacuated from urban areas in response to bombing raids, as was typical of many rural towns and villages.

The crew narrowly avoided the church tower and school, colliding with a stand of trees and landing in a field on the southern edge of the village.

Eight civilians as well as a soldier of the Czech Army billeted nearby rushed to the crash site and were able to pull all the crew members from the flaming wreckage, though only one survived.

[14] Following the outbreak of bovine spongiform encephalopathy in the late 20th century, the industrial estate at Wymington was one of 11 designated storage sites for meat and bonemeal resulting from culled cattle before incineration.

While the village is surrounded by farms, the land was never considered suitable for market gardening as is common in the rest of northern Bedfordshire.

One leads southwest, crossing underneath the Midland Main Line railway towards the village of Podington 1.6 miles (2.6 km) away.

Another leads north, crossing into Northamptonshire and passing through the village of Little Wymington before reaching central Rushden about 1.7 miles (2.7 km) away.

The Wymington Deviation, a 3.5 miles (5.6 km) railway curve and tunnel constructed in 1884 to create a gentler grade for heavily laden trains, is located immediately to the south and west of the village.

[32] According to data from the 2021 United Kingdom census, Wymington Parish had a population of 1,000, with a density of 3,311 inhabitants per square kilometre (8,580/sq mi).

By the 19th century, the shoe and boot industry in nearby Northamptonshire had led to the development of cottage shoemaking in the village and outside employment.

By the late 20th century, however, with increased automation and the decline of shoe and boot making, the economy began to return to one supported by agriculture, small industry, and services.

[34] As of late 2023, planning was ongoing to convert 10.6 hectares (26 acres) of fields adjacent to the industrial estate to a 10.5 MW solar farm.

[39] The medieval Gothic church was constructed in 1377 at the behest of John Curteys, a wealthy manor holder and mayor of the wool staple of Calais.

It was built in the decorated style and is noted for its brasses and surviving late Medieval art, including a large doom painted over the chancel arch.

The rededication ceremony included representatives of the United States Air Force from nearby RAF Alconbury, the Royal British Legion, and military reenactors.