[4] According to Inside Higher Ed, this decision was "partly out of concerns that accepting the funds could impair its ability to set its own policies around issues of sexual orientation and gender identity,"[5] and as of 2023, the college's website described this decision as being largely motivated by a concern that accepting this funding would allow the government to impose on the college's hiring and admission policies, such as birth control and same-sex marriage.

[10] In 2020 Paul McCown, a former Michigan politician and the school's chief financial officer (CFO) of two years, launched the distillery Sweetwater Spirits,[11] which switched to producing hand sanitizer at the onset of the COVID-19 pandemic.

In early 2021 he used claims of wealth from this business to secure a $15 million loan from investment firm Ria R Squared, before anonymously donating two-thirds of those funds to the college.

McCown also received $2 million in federally backed PPP loans, and was fired by the school in June 2021 when his fraudulent activity was discovered.

A subsequent internal investigation led to the dismissal of the school's director of horsemanship because of payments made with McCown's approval.

[14] Wyoming Catholic College initially stated that it would return the entire sum to Ria R Squared once it completed an internal investigation into the alleged fraud.

[21] The curriculum was designed to give students a general liberal arts education through a study of the Great Books.

Freshmen begin their four-year educational journey with a three-week backpacking trip in the Rocky Mountains, which the college considers "the most unusual and meaningful orientation program in the country".

[29] These policies have been suspended at times, for example during the fall 2019 semester when the campus experienced problems with landline phone and Internet connections.

[30] In July 2023, Inside Higher Ed published an article featuring Wyoming Catholic as representative of a trend that helps "students destress and build community".

[36][37] In the Spring of 2024, Wyoming Catholic College became the fifth site in the world to have a shrine dedicated to "Mary, Mother of Persecuted Christians."

[38] Wyoming Catholic has a dry campus and a code of conduct that "prohibits visitation between the sexes in student residence halls", as well as "sexual activity outside the confines of a marriage".

[39] The college was the inspiration for the setting of the 2019 play Heroes of the Fourth Turning by Will Arbery, which was nominated for the Pulitzer Prize in drama.