[2] Designed by Manchester City Architects Department under G. Noel Hill,[3] and completed in 1942,[4] the garage was a pioneering example of its type of construction.

It was the second-largest reinforced concrete shell roof structure to be constructed in England.

Wythenshawe Garage proved to be the model for much larger buildings using the concrete shell roof structure technique, which was an economic method of achieving large uninterrupted roof spans.

Originally designed to garage a hundred double-decker buses, the building on its completion was immediately commandeered by the Ministry of Aircraft Production for work associated with the building and repair of Avro Lancaster bombers in support of Britain's Second World War efforts.

It housed buses used mainly on routes linking the city centre and the large Wythenshawe housing estate, also on three serving Gatley and Styal, the Sale Moor and Brooklands districts of Sale, and Baguley and the Timperley district of Altrincham.