Wytheville was an affiliate of the Chicago Cubs (1985–1989), Atlanta Braves (1971-1973), Washington Senators II (1965, 1969), Cincinnati Reds (1967), Kansas City A's (1964), Minnesota Twins (1961-1963), Washington Senators I (1960), St. Louis Cardinals (1957-1959), Baltimore Orioles (1954), and St. Louis Browns (1953).
[1] Alumni include Jerome Walton, Tony Oliva, Reggie Smith, Joe Rudi, and Jeff Burroughs.
The 1960 Wytheville Senators captured the Appalachian League Championship.
Constructed in 1948, the ballpark hosted all Wytheville minor league teams during its existence.
Its grandstand and brick exterior are still in existence today within the park and a plaque recognizes the home plate location.