Lil Uzi Vert originally contacted TM88 through FaceTime while TM88 was in Miami to work with rappers Future and Gucci Mane.

When TM88 returned to Atlanta, he could not access his laptop, leading to him using an old computer and a Beats Pill speaker to produce the instrumental for "XO Tour Llif3".

[5] On February 26, 2017, Lil Uzi Vert released Luv Is Rage 1.5, an extended play consisting of four tracks, including "XO Tour Llif3", on their SoundCloud account.

[9] The story revolves around Lil Uzi Vert dealing with a drug addiction and his then girlfriend Brittany Byrd struggling with suicidal thoughts.

[16] Lil Uzi Vert references money numerous times on the track with one line stating "all my friends are dead" citing the use of deceased presidents on banknotes.

[21] Pitchfork writer Matthew Strauss stated, "Uzi resists total caricature with [their] liberal use of dark, manic details, and on 'XO TOUR Llif3' [they channel] the indulgence of dulled senses perfected by Future at his DS2 peak.

On March 13, 2017, an animated music video for "XO Tour Llif3" was released on Lil Uzi Vert's YouTube channel.

[35] The video, which has been quoted as "trippy", was animated by Andrew William Ralph and features a cartoon version of Lil Uzi Vert gripping a steering wheel while holding a lit blunt in between their fingers.

[40] Directed by Jered Harrison, the video shows an animated version of Uzi riding their motorcycle out of the cargo hold of an airplane and into a purple sky as dollar bills materialize in the air around them before landing in a crowd of fans.

[46] On March 6, 2020, Lil Uzi Vert released a "lyrically reflective" sequel to the song, simply titled "P2", as part of their second studio album, Eternal Atake.