[1] The film features two people born intersex: San Francisco bicycle messenger Kristi Bruce and clinical psychologist Tiger Devore.

Jorge Daaboul, medical director of Pediatric Endocrinology, Diabetes & Metabolism at Florida Hospital for Children, provides a clinical perspective.

[3] Jim's parents, Alice and John, discuss their experience raising a child born with a variation of sex anatomy.

Winston Wilde, Professor of Human Sexuality and Behavioral Sciences at Santa Monica College called the movie, "the finest film on the issues of intersex Americans, and an indispensable tool for instructors of Human Sexuality, Gender Identity, and Social Psychology.

"[9] Demonstrating continued relevance, The New Yorker published a feature on XXXY, "A New Era for Intersex Rights" on December 30, 2013.