Xanxerê (Portuguese pronunciation: [ʃɐ̃.ʃeˈɾe]) is a city in Santa Catarina, southern Brazil.

Italian and German are the mainstream cultures, having been brought by immigrants in the early 20th century through the migration of the "gauchos".

The city is one of the main production centers of maize in Brazil and serves as an important industrial, commercial and service center for western Santa Catarina.

Xanxerê is the headquarters of the Association of Cities of Alto Irani (AMAI), composed of 17 "municípios".

Many homes and businesses were severely damaged or destroyed, two people died, and another 120 were injured.