Ghali was born in 1989 in Paris, France and was raised in Athens, Greece to a Greek mother and Egyptian father.
[2] After earning her bachelor's degree, Ghali enrolled in the Film Scoring, Music Composition and Production Master's program at New York University.
In August 2014 she signed with Pitbull's record label Mr 305 and released her debut single "Broken" with Katt Rockell; the track hit Top 30 on US Dance radio.
Ghali released a slightly different version of "Broken" in Greek with Tamta titled "Gennithika Gia Sena".
In summer of 2014 she collaborated with Greek Pop star Sakis Rouvas and co-wrote and produced his single "Open Eyes" which he performed at the World Music Awards.
Ghali's single, "Places", was released at the end of 2016 and features vocals from singer-songwriter and actress Raquel Castro.
[15] Regarding the story behind the release on Syrup Music, the female artist revealed the following: "EDX was actually one of the DJs who received the song.
[16] On September 27, 2019, Xenia Ghali's beat from "Black Betty's Worldwide" was used as a sample in "Get Ready" by Pitbull featuring Blake Shelton.
The song released as a single on January 30, 2020, and the music video premiered on Pitbull's YouTube channel on February 10, 2020.
Ghali has DJed at clubs including the Ministry of Sound, Cavo Paradiso, Cielo and Nikki Beach and has played alongside DJs including Steve Aoki, Erick Morillo, Martin Solveig, Don Diablo, DubVision, Cedric Gervais and Jay Hardway.