In his three years playing for the Basel first-team, he was an important player in the team that won three Swiss Super League titles.

[15] At the end of the 2011–12 season, for the second time in his Basel stint, he won the Double, consisting of the League title,[16] and the Swiss Cup.

[17] On 9 February 2012, Basel announced that Shaqiri had accepted a transfer to German club Bayern Munich of the Bundesliga for the 2012–13 season.

[19] He faced competition for a place in the midfield from established internationals Franck Ribéry, Arjen Robben, Toni Kroos and Thomas Müller.

[21] Shaqiri did not score his first Bundesliga goal until the final league match of the 2012 calendar year, rescuing a point for them in a 1–1 draw with Borussia Mönchengladbach, leaving Bayern in first place at the winter break.

Although he did not play in the final, Shaqiri won the 2012–13 UEFA Champions League title with Bayern, as well as the Bundesliga and the DFB-Pokal title, making him one of the Bayern Munich players to have won the first treble in club history; he added the UEFA Super Cup and FIFA Club World Cup to his achievements that year.

[31] Four days later, he registered his first European tournament goal for Inter, scoring the opener from a Zdravko Kuzmanović assist in a 3–3 UEFA Europa League draw away to Celtic.

[36][37] He made his debut eleven days later in a 1–1 draw with Norwich City at Carrow Road, assisting Mame Biram Diouf's headed goal with a free kick.

[41][42] However a calf injury ruled him out for the next six weeks, returning to the side on 24 September 2016 against West Bromwich Albion where he provided the assist for Joe Allen in a 1–1 draw.

[61] He made his first full start on 22 September, in a 3–0 win over Southampton, and received praise for his performance which earned him the BBC Sport man of the match award.

[65] In November, he was left out of the club's Champions League trip to Red Star Belgrade in Serbia to avoid controversy over his pro-Albanian views.

[66] The following month, during the North West derby, Shaqiri scored twice after coming on as a substitute to guide Liverpool to a 3–1 win which saw the club record a league victory over Manchester United for the first time since March 2014.

[70][71] On 14 August, Shaqiri picked up his second trophy with the club, winning the UEFA Super Cup against Chelsea on penalties after a 2–2 regular finish.

[72] On 4 December, following a prolonged injury,[73] Shaqiri scored his first goal of the 2019–20 season in the derby against Everton, slotting home Liverpool's second in a 5–2 win.

[75] In June 2020, Liverpool were crowned Premier League champions,[76] and Shaqiri received a medal as he made the required number of appearances for one.

[79] Less than six months later, having been involved in just half of their Ligue 1 matches during the campaign and started only nine times, it was reported that he could return to Switzerland and join FC Sion.

"[80] On 9 February 2022, Shaqiri joined Major League Soccer club Chicago Fire on a contract that was to run through the 2024 season as a Designated Player.

[81][82] The transfer reunited him with Georg Heitz, Chicago Fire's sporting director, who previously worked at FC Basel early in Shaqiri's career.

[84] On 16 August 2024, two days after leaving the Chicago Fire, Shaqiri returned to FC Basel, rejoining on a three-year contract.

[88] On 11 September 2012, Shaqiri did not sing the Swiss national anthem in a World Cup qualifier against his ancestral Albania in Lucerne, and did not celebrate when he scored the opening goal of a 2–0 win.

He and fellow goalscorer Granit Xhaka, who is also of Kosovar descent, celebrated their goals by making an eagle gesture, a symbol of ethnic Albanians.

[98][99][100][101] Switzerland captain Stephan Lichtsteiner, who is not of Albanian origin, did the same gesture to celebrate Shaqiri's goal, and defended both players after the match.

[103][104] Additionally, with the goal he equalled Stéphane Chapuisat's tally of 21 in internationals and entered Switzerland's top ten scorers of all time.

[110] On 15 November 2021, Shaqiri became only the fifth Swiss player to reach 100 caps when he started Switzerland's final 2022 World Cup qualifier against Bulgaria.

[117] Shaqiri primarily plays as a right winger and FIFA's official website describes him as "unpredictable on the ball, adept with both feet, clinical in front of goal and possessing excellent vision.

He's left footed, but comfortable and equally effective on either wing or as a classic play-maker, boasting good vision and almost zero back lift in his passing and shooting."

He also added that Shaqiri's "tricks," "direct running style," and "composure," made him "a player who's dangerous in almost any attacking area."

However, while he acknowledged the young winger's promising talent and potential to become a top player, he also noted that he had a poor work rate and lacked maturity.

He wears Nike Mercurial Vapor boots, and at the 2018 World Cup he had the flags of Switzerland and Kosovo embroidered on each heel.