Xue Xu (died c. 271) was a Chinese military general and politician of the state of Eastern Wu during the Three Kingdoms period of China.
Xue Xu's ancestral home was in Zhuyi County (竹邑縣), Pei Commandery (沛郡), which is around present-day Suzhou, Anhui.
He was the eldest son of Xue Zong, a notable official and scholar of the Eastern Wu state.
Yu Si, an army supervisor, and Tao Huang, the Administrator of Cangwu Commandery (蒼梧郡), served as Xue Xu's subordinates.
Wu Yan, then a low-ranking official, was taken aback by the sight of Xue Xu's army marching towards Jiaozhi Commandery.