His major roles are Josuke Higashikata in JoJo's Bizarre Adventure: Diamond Is Unbreakable, Taiga Kagami in Kuroko's Basketball, Zenkichi Hitoyoshi in Medaka Box, Kaname Tsukahara in Kimi to Boku, Masayuki Hori in Monthly Girls' Nozaki-kun, Jun Isashiki in Ace of Diamond and Ultraman Belial in the recurring Ultraman Series.
During his high school years, Ono aimed to become a professional soccer player and at one point was scouted by the Shimizu S-Pulse.
In addition to meeting the voice actor in person at an anime event, this inspired him to pursue the same career.
[4][5] In August 2011, Ono formed the voice acting unit You-Tak (ゆーたく, Yū-Taku) alongside Takuya Eguchi.
[9][10][11] On October 2, 2017, Ono announced his marriage from the last seven years prior in his blog post.