In 2006 he became the first modern-era golfer to make two hole in one shots in the same round of a PGA Tour event,[2][3] at the Reno-Tahoe Open in Nevada.

In December 2002, he announced his decision to turn pro before his upcoming graduation.

In April 2017, Miyazato won his fourth event on the Japanese Tour, The Crowns, followed two weeks later by another win in the Japan PGA Championship Nissin Cupnoodles Cup.

At the 2017 Indonesian Masters, Miyazato finished in solo 4th, earning enough Official World Golf Ranking points to finish the year in the Top 50, thus earning an invitation to the 2018 Masters Tournament, his first appearance.

His younger sister, Ai Miyazato, was also a professional golfer and competed on the LPGA Tour.