The channel provides 24-hour rolling news coverage focused primarily on central portions of upstate New York.

In February 2007, News 10 Now launched a separate feed focused on Binghamton, Elmira, Corning and surrounding areas; the expansion resulted in the hiring of five reporters and a technician that would be based from newly created bureaus located in Vestal and Corning, as well as the addition of four producers at the Syracuse headquarters, who work exclusively on content for the Southern Tier feed.

News 10 Now's live coverage of the American Civic Association shooting in April 2009, was carried nationally by CNN.

[3][4] On September 20, 2016, with Charter Communications' acquisition of Time Warner Cable, the channels were re-branded as "Spectrum News.

Just before the end of 2020, during the region’s most serious surge of COVID-19, Spectrum laid off an undisclosed but significant number of its local news staff,[9] including founding news director Ron Lombard, anchors Tammy Palmer and Iris St. Meren, and longtime photographer Tom Walters among others.

The remaining staff was asked to record news reports on their mobile devices and anchoring was done from Albany.