He was the son of Rabbi Joseph Reischer, author of Giv'ot 'Olam, and a pupil of R. Simon Spira of Prague.
Reischer married Spira's granddaughter, the daughter of his son Benjamin Wolf.
He was subsequently called to the rabbinate of Ansbach, and then occupied a similar position at Worms, from 1713 to 1716, when he went to Metz, officiating there until his death in February 1733.
The Life and Works of Rabbi Jacob Reischer, by Rabbi Rudolph J Adler (Thesis, Dissertation; New York: Yeshiva University, 1960) Abstract: "In the following pages an endeavor will be made to write a biography of Jacob Reischer based upon his works and many writings of his contemporaries.
Correspondence with official record keepers and historians from the cities in which our rabbi flourished has helped to make this account more complete."