The Yamaha YZR500 was a 500 cc Grand Prix racing motorcycle made by Yamaha from 1973 through 2002.

It achieved significant acclaim, especially during the 1980s and 1990s.

The YZR500 was ridden by championship winners Giacomo Agostini (1975), Kenny Roberts (1978, 1979, 1980), Eddie Lawson (1984, 1986, 1988) and Wayne Rainey (1990, 1991, 1992).

Phillip McCallen won the Macau Grand Prix in 1996.